McArdle disease may increase the risk of a malignant hyperthermia-type of reaction to anesthetic agents .
Rhabdomyolysis, acute renal failure and electrolyte abnormalities may ensue.
Although a very small risk, it is advisable to inform the anesthetist of the risk prior to any surgery. Choice of low risk agents and careful monitoring can further lower the risk.
 McArdle’s disease and anaesthesia: case reports. Review of potential problems and association with malignant hyperthermia. Bollig G, Mohr S, and Raeder J (2005) Acta Anaesthesiol Scand 49: 1077-1083.
People with McArdle disease are at increased risk of developing compartment syndrome through use of tourniquets .
Prior to surgery, advise the surgeon of the risk.
Limit length of use of blood pressure cuffs.
 Acute compartment syndrome after forearm ischemic work test in a patient with McArdle’s disease. Lindner A, Reichert N, Eichhorn M, and Zierz S (2001) Neurology 56: , 1779-1780.
Patients may be at risk of cramping when holding an awkward position for examination or treatment.
McArdle Disease Medical Overview