McArdle Disease medical overview
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EXERCISE AND DIET
Relatively gentle aerobic exercise is very beneficial for people with McArdle disease  – it helps to improve their aerobic metabolism.
Exercise is helpful with the important task of keeping weight under control.
People with McArdle disease, no matter what age they are, need to have a regular exercise routine.
At least 45 minutes of aerobic exercise, after attaining ‘second wind’ (page 12f), five times a week, is strongly recommended .
The common mantra ‘No pain, no gain’ is wrong in McArdle disease.
Studies suggest that aerobic training is safe, with improvements in physiological parameters after several weeks. Controlled trials are needed to fully assess the therapeutic effect .
If patients are very de-conditioned they need to start their exercise routine very carefully. This should be done under the supervision of a McArdle specialist.
Information to support training of people with McArdle’s is available (page 14f).
 Aerobic conditioning: an effective therapy in McArdle’s Disease. (2006) Haller RG, Wyrick P, Taivassalo P, et al. Ann Neurol; 59: 922e8.
 Exercise capacity in a 78 year old patient with McArdle’s disease: it is never too late to start exercising. Perez, M. et al. (2006) Br J Sports Med 40: 725-726.
 The ‘McArdle paradox’: exercise is good advice for the exercise intolerant. Lucia A, Quinlivan R, Wakelin A, Martín MA, Andreu, AL, et al. (2012) Br J Sports Med doi: 10.1136.
 Exercise and Preexercise Nutrition as Treatment for McArdle Disease. Nogales-Gadea G, Santalla A, Ballester-Lopez A, Lucia A, et al. (2016) Med Sci Sports Exerc. PMID: 26559449.
McArdle Disease Medical Overview